Biochemistry

Question: Compargon the mechanisms of action of the following 3 enzymes: i) pyruvate dehydogenase ii) isocitrate dehydrogenase iii) alphaketo glutarate dehydrogenase. event role: Enzymes are substances that act as a throttle valve to eviscerate under ones skin about a specify biochemical reaction. Each enzyme is specific to various reactions. Pyruvate dehydogenase (from Carbohydrate Catabolism) ,isocitrate dehydrogenase (from the Krebs nonchalant round),and alphaketo glutarate dehydrogenase (from the Krebs Cycle) are three of many enzymes whose mechanisms impart be discussed. Pyruvate and acetyl group radical CoA are important metabolites at the crossing of many carbon-metabolising roadways. In order for pyruvate to be converted to acetyl Coa, aerobic decarboxylation needs to take place. The enzyme that drives this reaction is pyruvate dehydogenase. Pyruvate dehydrogenase is known as the counterbalance component enzyme of the pyruvate dehydrogenase labyrinthia n (PDC). Pyruvate dehydrogenase is a complex enzyme consisting of four-fold copies of three subunits E1-Pyruvate dehydrogenase ,E2-Dihydrolipoyl transacetylase ,E3-Dihydrolipoyl dehydrogenase .This complex aids in trans melodic lineing pyruvate into acetyl-CoA(used in the Krebs cycle for respiration purposes) by pyruvate decarboxylation.

Pyruvate dehydrogenase(Pdh) therefore links the glycolysis metabolic pathway to the kreb cycle cathartic energy via NADH. Pdh is regulated by 4 reversible, inhibitory kinases of E1. The kinases obligate differing tissue specificities. The kinases are activated by incre asing the ratios of: [NADH]/[NAD],[acetyl Co! A],[ATP]/[ADP]. The kinases are inhibited by pyruvate.Insulin stimulates dephosphorylyation.  This is reversed by pyruvate dehydrogenase phosphatase. Pyruvate dehydrogenase phosphatase is stimulated by insulin, PEP, and AMP, but competitively inhibited by ATP, NADH, and Acetyl-CoA. The ylide resonance form of thiamine pyrophosphate (TPP) begins by attacking the electrophilic ketone of pyruvate. The mediate ?-alkoxide...If you want to get a full essay, order it on our website: OrderCustomPaper.com

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